The game was tied at 35 when West's 4-yard TD capped a 74-yard drive with 7:39 left in the third quarter.
Enders added a 40-yard romp with 2:32 remaining to seal the victory for the Tigers (4-4, 3-2 Colonial Athletic Association).
West rushed for 144 yards and Enders had 122 as the Tigers rolled up 321 yards on the ground. Enders was 16 of 28 for 269 passing yards, including a 78-yard TD to West to give Towson a 21-14 lead late in the first quarter.
For the Wildcats (6-3, 4-2), John Robertson also threw for four touchdowns on 17-of-23 passing for 216 yards and ran for a 5-yard score.
Villanova's Kevin Monangai added 103 yards rushing and caught two touchdown passes.
Ohio State quarterback Cardale Jones was taken to a hospital Wednesday night and treated for a migraine headache, according to multiple media reports.
The Florida Gators will start Treon Harris at quarterback in Saturday's opener vs. New Mexico State over redshirt freshman Will Grier, coach Jim McElwain said Tuesday.
Baylor University has hired a Philadelphia law firm to independently investigate the university's handling of sexual assault complaints, including one against defensive end Sam Ukwuachu.
Oregon State and former coach Mike Riley face a federal Title IX lawsuit filed by a woman who said she was raped as a result of the coach's failure to correct a sexually violent culture.
James Madison players will wear decals on their helmets during Saturday's season-opening game in memory of the two journalists who were killed during a live television broadcast.
Los Angeles prosecutors have charged a man in connection with the theft of the University of Southern California's copy of O.J. Simpson's Heisman Trophy more than 20 years ago.