Hedrick replaced Southwick in the fourth quarter, well after the game was decided. He led the Broncos (8-2, 5-1 Mountain West) on a 56-yard drive of more than 9 minutes, capping it off with a 4-yard touchdown run.
Boise State was looking to recover from a bitter home loss last week to San Diego State, an upset that thwarted the Broncos' hopes of reaching a BCS bowl game this year.
In Honolulu, Boise State made sure the game's outcome was rarely in doubt. The Broncos defense finished with six sacks, three fumble recoveries and two interceptions. The sacks pushed down Hawaii's rushing total to -14 for the game.
Hawaii (1-8, 0-6) had its best play on special teams, with Mike Edwards returning a kickoff 100 yards for a touchdown to tie the game at 7-7 in the first quarter.
Quarterback Sean Schroeder of Hawaii was benched midway through the third quarter. He finished with 100 yards and an interception, while taking four sacks.
A crowd generously announced at just over 24,000 -- including many orange shirt-wearing Broncos fans -- cheered loudest when Schroeder was pulled from the game with roughly six minutes left in the third quarter. His backup, sophomore Jeremy Higgins, went on to complete one more pass, with 154 yards and an interception.
Higgins led the Warriors on their only offensive scoring drive of the game, a 10-play, 72-yard drive resulting in a 1-yard touchdown run for John Lister.
Will Gregory, who picked Hawaii over Boise State because he wanted to play running back instead of defense, was ejected in the first quarter for throwing a punch at an opposing player after a kickoff.
Michigan coach Jim Harbaugh said Tuesday he has informed competing quarterbacks Jake Rudock and Shane Morris of his decision on a starter for the Wolverines' opener Thursday night at Utah.
Michigan State quarterback and Heisman Trophy hopeful Connor Cook said he was disappointed his teammates didn't vote him among the team's three captains this season.
No. 5 Michigan State will start redshirt freshman Vayante Copeland at one of its two cornerback spots Friday night at Western Michigan.
Kyle Flood says he expects to be on the sideline leading Rutgers in its opener despite an investigation into whether he improperly communicated with a faculty member about a player's status.
Less than four months removed from his transfer to Florida State, Everett Golson has been named the Seminoles' starting quarterback.
After hinting at it for more than a week, LSU coach Les Miles confirmed Monday that Brandon Harris will start at quarterback in Saturday's opener against McNeese State.