Glennon connected twice for touchdowns with Tobais Palmer in a span of 51 seconds late in the third quarter to propel the Wolfpack. Glennon finished 24 of 37 for 245 yards.
Amerson snagged a pass that deflected off the hands of Boston College receiver Colin Larmond Jr., recording his 18th career pick and darting back for a 55-yard score 27 seconds before halftime. N.C. State improved to 12-2 when Amerson records an interception, including 5-0 this season.
The Wolfpack overcame a shaky offensive performance in the first half -- one fumble, six punts -- to clinch a third consecutive winning season. With the loss, the Eagles (2-10, 1-7) capped the program's worst season since the 1978 team finished 0-11.
BC's Rolandan Finch (19 carries, 144 yards) scored from 4 yards out with 5:18 left in the third quarter to cut the lead to 14-10, but that was as close as the Eagles (2-10, 1-7) would get.
Glennon found Palmer for an 8-yard score on the next drive. Then, after Juston Burris recorded the Wolfpack's third interception of Chase Rettig, Glennon hit Palmer for a 25-yard score and a 27-10 lead.
Glennon's season total of 3,648 yards is second on the school's all-time list, behind Philip Rivers. Glennon is the first player in N.C. State history to record multiple 30-touchdown seasons. He had 31 last season and 30 this year.
The loss potentially marked the end of Frank Spaziani's tenure as Boston College's head coach. The Eagles won 15 games his first two seasons but were just 6-18 since.