With the win, UCF (9-3, 7-1) clinched Conference USA's East Division title and will face Tulsa in the conference championship game next Saturday. McDuffie had scoring runs of 9, 8 and 43 yards in his final home game for Central Florida.
Bortles, who completed 17 of 23 for 225 yards, hit J.J. Worton with scoring passes of 18 and 4 yards. Lyle Dankenbring returned an interception 78 yards for a score as the Knights took advantage of numerous Blazer mistakes to jump out to a 35-10 halftime lead.
Jonathan Perry threw for 307 yards, two touchdown passes and a rushing score for UAB (3-9, 2-6).
UAB outgained UCF 322-237 in the first half, but three drives inside the Knights' 20-yard line ended with no points.
Will Grier threw four touchdown passes to four receivers -- all in the first half -- and No. 25 Florida upset third-ranked Mississippi 38-10 on Saturday night.
Leonard Fournette highlighted his SEC-record third straight 200-yard game with a 75-yard touchdown run, and No. 9 LSU overcame Eastern Michigan 44-22 on Saturday night.
Florida State running back Dalvin Cook exited in the first quarter of the Seminoles' 24-16 win over Wake Forest with a left hamstring injury. He is day-to-day.
Trevone Boykin threw five touchdown passes, including four to freshman KaVontae Turpin, and No. 4 TCU rode a 30-point first quarter to a 50-7 rout of Texas on Saturday.
As if things weren't going bad enough at Texas, the Longhorns appear to have players on Twitter during lopsided losses and jabs at their coach accidentally being sent from other nearby teams.
Tulane long-snapper Aaron Golub became the first legally blind person to play in a Division I football game Saturday, according to the school.