With the win, UCF (9-3, 7-1) clinched Conference USA's East Division title and will face Tulsa in the conference championship game next Saturday. McDuffie had scoring runs of 9, 8 and 43 yards in his final home game for Central Florida.
Bortles, who completed 17 of 23 for 225 yards, hit J.J. Worton with scoring passes of 18 and 4 yards. Lyle Dankenbring returned an interception 78 yards for a score as the Knights took advantage of numerous Blazer mistakes to jump out to a 35-10 halftime lead.
Jonathan Perry threw for 307 yards, two touchdown passes and a rushing score for UAB (3-9, 2-6).
UAB outgained UCF 322-237 in the first half, but three drives inside the Knights' 20-yard line ended with no points.
If you're not a preseason Heisman favorite, you need to grab the nation's attention with big plays in big games. Here are the games where 10 hopefuls can make their mark on the Heisman race.
With so much uncertainty at offensive tackle, the Boilermakers will be counting on newcomer Jalen Neal to make an immediate impact.
David Sills, who once committed to Lane Kiffin at USC in seventh grade, is leaving West Virginia to purse his dreams of playing quarterback.
Alleged 1998 rape victim Brenda Tracy said she left Lincoln, Nebraska, with an advocate for her cause in football coach Mike Riley.
There are plenty of questions surrounding Oregon State's offensive trio, but with some consistency this group should rank higher by season's end.
Ole Miss will get a chance to prove itself in the early going when it faces Dalvin Cook and a loaded Florida State team in Week 1.