With the win, UCF (9-3, 7-1) clinched Conference USA's East Division title and will face Tulsa in the conference championship game next Saturday. McDuffie had scoring runs of 9, 8 and 43 yards in his final home game for Central Florida.
Bortles, who completed 17 of 23 for 225 yards, hit J.J. Worton with scoring passes of 18 and 4 yards. Lyle Dankenbring returned an interception 78 yards for a score as the Knights took advantage of numerous Blazer mistakes to jump out to a 35-10 halftime lead.
Jonathan Perry threw for 307 yards, two touchdown passes and a rushing score for UAB (3-9, 2-6).
UAB outgained UCF 322-237 in the first half, but three drives inside the Knights' 20-yard line ended with no points.
Florida State coach Jimbo Fisher hopes quarterback Sean Maguire is ready to go full speed by the middle of June.
Graduate transfer quarterback Davis Webb has officially joined California, giving the Golden Bears an experienced option to replace No. 1 overall NFL draft pick Jared Goff.
First-year football coach Dino Babers, hired by former Syracuse AD Mark Coyle, is on the committee that will search for Coyle's replacement.
Hugh Freeze has some major holes to fill on offense with the departures of Laremy Tunsil and Laquon Treadwell, but there is Chady Kelly and good depth.
After transferring in from Montana State, Dakota Prukop has a checklist he's working from as he prepares to compete for the Oregon job.
The destination for Week 6 of the Big 12 Ultimate Road Trip is unanimous, as all three conference reporters would head to the Red River Rivalry.