The Golden Flashes, coming off the best season in school history, were without running back Dri Archer, being touted by the school as a potential Heisman Trophy candidate who suffered a leg injury early in the game. He had 10 yards on 3 carries.
Reardon, replacing a four-year starter who led Kent State to its first bowl appearance in 40 years, led a game-winning 88-yard drive. He hit Humphrey for his second touchdown pass with 4:28 to play.
The Flash defense stopped the Flames on downs at the Kent State 40 with just more than a minute to go.
Kent State had to overcome nine penalties in coach Paul Haynes' debut to run its regular-season winning streak to 11.
Running back Devontae Booker had 124 combined yards and a touchdown, and Utah spoiled Jim Harbaugh's Michigan coaching debut, beating the Wolverines 24-17 on Thursday night.
Arizona star linebacker Scooby Wright will have an MRI after injuring his left knee in the first quarter of the Wildcats' season-opening 42-32 win over UTSA on Thursday night.
Trevone Boykin threw for 246 yards and a touchdown and ran for 92 yards and another score to help No. 2 TCU outlast Minnesota 23-17 on Thursday night.
All-American defensive end Shawn Oakman and safety Orion Stewart have been suspended for Baylor's season opener Friday against SMU for a violation of team rules, a school spokesman told ESPN.com.
Ohio State quarterback Cardale Jones is "doing fine" after he was released from the hospital Wednesday night after being treated for symptoms related to a migraine headache.
East Carolina receiver Trevon Brown will miss three games after being placed on probation for a violation of the school's student code of conduct.