Eastern Illinois (1-0) snapped a 19-19 tie when Taylor Duncan capped a 12-play 75-yard drive with a two-yard TD run with 7:36 left in the third quarter.
Duncan, who rushed for 94 yards on 20 carries, would cap the night with a 45-yard TD run with 4:40 left.
Eastern Illinois built a 19-13 lead at halftime as Garoppolo completed 15 of 24 passes for 246 yards and threw touchdown passes of 37 and four yards to Lora and a 62-yard strike to Keiondre Gober that snapped a 13-13 tie with 3:22 left in the first half.
Lora caught 10 passes for 87 yards.
San Diego State (0-1) got a 48-yard touchdown run from Colin Lockett in the first quarter.
Mississippi says starting left tackle Laremy Tunsil will not play in Saturday's game against UT Martin because of an ongoing investigation by the NCAA.
Arizona linebacker Scooby Wright's left knee injury is not season-ending, according to an MRI Wright had after Thursday night's opening win over UTSA, sources told ESPN's Brett McMurphy.
Syracuse starting quarterback Terrel Hunt has a significant injury to his right Achilles, head coach Scott Shafer said after the Orange's season-opening 47-0 rout of Rhode Island.
The Mountain West told ESPN's Brett McMurphy that officials correctly ruled the final play that kept Colorado from getting a potential game-tying touchdown against Hawaii before time expired.
ESPN 300 running back Elijah Holyfield, the son of former heavyweight boxing champion Evander Holyfield, has decided to stay home and attend Georgia, he announced Friday.
Miami reserve linebacker Al-Quadin Muhammad has been suspended for the season opener against Bethune-Cookman on Saturday for a violation of team rules, a source confirmed to ESPN.com