Fleming passed for 110 yards and ran for 38, before leaving in the third quarter because of leg cramps. He did not return.
The Delta Devils (0-1) of the Southwestern Athletic Conference struggled with the Rattlers defense as quarterbacks Patrick Ivy and Jeremy Collins combined to throw three interceptions and were held to 88 yards passing. Ivy ran for 74 yards, including a 64-yarder.
The Rattlers (1-0) of the Mid-Eastern Athletic Conference took a 20-0 lead into halftime behind touchdown runs from Fleming and Albert and two short field goals by Chase Varnadore.
Mississippi Valley State closed to 20-10 after Collins scored on a 2-yard sneak with 10:21 remaining in the fourth quarter.