BOISE, Idaho -- Joe Southwick threw five touchdown passes as Boise State pounded overmatched Tennessee-Martin 63-14 on Saturday.
Boise State (1-1) rebounded from its worst defeat in eight years, a 38-6 loss at Washington last week that knocked them from the Top 25.
Tennessee-Martin (1-1), an FCS team from the Ohio Valley Conference, could do little to stop Boise State's hurry-up offense.
This was the first meeting between the programs, and the longest trip west Tennessee-Martin has made for a football game.
Boise State, which has won 12 consecutive home openers on the blue turf at Bronco Stadium, led 49-7 at halftime. They substituted freely in the second half.
Tennessee-Martin fell to 1-15 against FBS programs in its history, beating Memphis last season.
Southwick, who was pulled from the game early in the second half, completed 17 of 25 passes for 234 yards. He was not intercepted.
Tennessee-Martin quarterback Dylan Favre completed 15 of 22 passes for 155 yards and was intercepted three times. DJ McNeil led the Skyhawks in rushing with 87 yards and Jeremy Butler caught 9 passes for 118 yards.
Boise State scored first when Ajayi ran 11 yards up the middle for a touchdown to cap a 9-play, 70-yard drive in the first quarter.
Tennessee-Martin replied with a 75-yard drive requiring 13 plays. Favre, a nephew of NFL great Brett Favre, threw an 11-yard touchdown pass to Trent Garland to tie the score at 7-7 with 2:49 left in the first quarter.
Then the wheels fell off for the Skyhawks.
Boise State struck right back on the next series, with Southwick lofting a 54-yard scoring pass to a wide-open Aaron Burks for a 14-7 lead.
Then Boise State recovered an on-side kick at the Tennessee-Martin's 43. Southwick's 5-yard touchdown pass to Matt Miller gave the Broncos a 21-7 lead in the opening seconds of the second quarter.
After Tennessee-Martin turned the ball over on downs, Boise State drove 63 yards on a series aided by two pass interference calls against the Skyhawks. Ajayi's touchdown run from the 11 lifted Boise State to a 28-7 lead.
Jarod Neal replaced Favre at quarterback for the Skyhawks, but his first pass was intercepted by Bryan Douglas and returned 33 yards for a touchdown that gave Boise State a 42-7 lead with 5:03 left in the second quarter.
The Skyhawks fumbled the ensuing kickoff and Boise State recovered at Tennessee-Martin's 15. Southwick fired a touchdown pass to Shane Williams-Rhodes for a 49-7 lead.
The second half started much the same. On a fourth-and-7 play, Southwick threw a 30-yard touchdown pass to Williams-Rhodes for a 56-7 lead.
Backup quarterback Grant Hedrick ran 50 yards for a touchdown midway through the third for a 63-7 Boise State lead.
DJ McNeil scored on a 4-yard-run for the Skyhawks with 13:08 left in the game.
Will Grier threw four touchdown passes to four receivers -- all in the first half -- and No. 25 Florida downed third-ranked Mississippi 38-10 on Saturday night.
Leonard Fournette highlighted his SEC-record third straight 200-yard game with a 75-yard touchdown run, and No. 9 LSU overcame Eastern Michigan 44-22 on Saturday night.
An officiating error led to an Oklahoma State touchdown Saturday in the Cowboys' 36-34 win over Kansas State.
Texas A&M receiver Ricky Seals-Jones, who was ejected for targeting midway in the second quarter of Saturday's game, took to Twitter late in the game, retweeting a tweet that questioned the call.
Florida State running back Dalvin Cook exited in the first quarter of the Seminoles' 24-16 win over Wake Forest with a left hamstring injury. He is day-to-day.
As if things weren't going bad enough at Texas, the Longhorns appear to have players on Twitter during lopsided losses and jabs at their coach accidentally being sent from other nearby teams.