Wiltz scored his three touchdowns in the first half as the Cowboys (2-0) opened a 37-14 lead. He finished with 115 yards on 12 carries.
Stroud threw both touchdown passes in the third quarter, 33 yards to Ernest Celestie and 12 yards to Dylan Long. Stroud was 21 of 30 for 251 yards, becoming the fifth quarterback in school history to exceed 5,000 career passing yards.
McNeese had 528 yards of offense while holding the Golden Lions (0-2) to 216 yards. Arkansas-Pine Bluff has been outscored 120-25 in two games.
The Golden Lions tied the game at 14 on a 2-yard run by Jeremiah Young in the opening minute of the second quarter. The Cowboys then ran off the next 44 points.
Arizona linebacker Scooby Wright's left knee injury is not season-ending, according to an MRI Wright had after Thursday night's opening win over UTSA, sources told ESPN's Brett McMurphy.
The Mountain West told ESPN's Brett McMurphy that officials correctly ruled the final play that kept Colorado from getting a potential game-tying touchdown against Hawaii before time expired.
ESPN 300 running back Elijah Holyfield, the son of former heavyweight boxing champion Evander Holyfield, has decided to stay home and attend Georgia, he announced Friday.
Miami reserve linebacker Al-Quadin Muhammad has been suspended for the season opener against Bethune-Cookman on Saturday for a violation of team rules, a source confirmed to ESPN.com
All-American defensive end Shawn Oakman and safety Orion Stewart have been suspended for Baylor's season opener Friday against SMU for a violation of team rules, a school spokesman told ESPN.com.
Ohio State quarterback Cardale Jones is "doing fine" after he was released from the hospital Wednesday night after being treated for symptoms related to a migraine headache.