The Hawkeyes (3-1) now enter Big Ten play with a three-game winning streak, their longest since 2010.
Martin-Manley scored on returns of 83 and 63 yards early in the second quarter as Iowa jumped out to a 38-3 halftime lead.
Lowery took back picks for 35 and 13-yard TDs for Iowa, which scored its most points since it had 62 against Northwestern in 2002.
Tyler Van Tubbergen had 114 yards passing for the Broncos (0-4).
Nike Men's Iowa Hawkeyes Black/Gold Team Issue Performance PoloShop
Tennessee coach Butch Jones and Vanderbilt coach Derek Mason discuss their preparations for Week 13.
SEC Network's Greg McElroy and Jabari Greer discuss how Georgia will be able to contain Georgia Tech's offense.
South Carolina's loss to The Citadel, coupled with Georgia and Florida struggling in tight victories, was an embarrassment for the conference.
Needing a win to clinch the MAC West title, Northern Illinois falls short as Ohio stuns the Huskies 26-21.
Greg Windham and J.D. Sprague each threw a touchdown pass, Josiah Yazdani kicked four field goals and Ohio kept Northern Illinois from advancing to the Mid-American Conference title game with a 2
SEC Now recognizes the SEC players named as college football award finalist.