UConn turned the ball over five times and remains winless through four games. The Huskies struggled to find any offense behind quarterback Chandler Whitmer, increasing the pressure on third-year Connecticut head coach Paul Pasqualoni.
Buffalo (2-2) scored through the air, on the ground and on defense in building a 28-12 halftime lead. They blocked a field goal and scored 17 points off Connecticut turnovers.
Bulls quarterback Joe Licata passed for a career-high three touchdowns, connecting with different receivers on each score. Licata found tight end Mason Schreck for a 5-yard touchdown in the first quarter, later adding a 22-yard touchdown to Alex Neutz and a 36-yard score to Fred Lee.
The Bulls were aided by the return of starting running back Branden Oliver, who had 110 total yards including 90 yards rushing and a touchdown.
Whitmer turned the ball over four times, including a second-quarter interception that Najja Johnson returned 33 yards for a Bulls touchdown.
Patrick Clarke hit field goals of 49 and 50 yards for Buffalo.
Receiver Geremy Davis was a bright spot for the Huskies, with five catches for 102 yards.
The Huskies continue to have trouble on the ground. Entering the game 121st in rushing offense, they finished the game with 27 yards rushing on 39 attempts.
The win was Buffalo's first against a BCS school since Sept. 7, 2002, when they beat Rutgers.
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Despite battling the flu all week, Will Grier will start at quarterback for No. 25 Florida on Saturday when the Gators host No. 3 Ole Miss.
Florida State running back Dalvin Cook exited in the first quarter of the Seminoles' 24-16 win over Wake Forest with what coach Jimbo Fisher called a left hamstring injury.
Trevone Boykin threw five touchdown passes, including four to freshman KaVontae Turpin, and No. 4 TCU rode a 30-point first quarter to a 50-7 rout of Texas on Saturday.
As if things weren't going bad enough at Texas, the Longhorns appear to have players on Twitter during lopsided losses and jabs at their coach accidentally being sent from other nearby teams.
Tulane long-snapper Aaron Golub became the first legally blind person to play in a Division I football game Saturday, according to the school.
LJ Scott ran for 146 yards and two touchdowns, and No. 2 Michigan State held on through a lackluster second half to beat Purdue 24-21 on Saturday.