Pruneau opened the scoring for the Crimson (5-0) with a 2-yard pass to Cameron Brate in the first quarter. Stanton Jr. ran for a 3-yard touchdown in both the second and third quarters.
Pruneau tossed two more touchdowns in the fourth quarter, a 50-yard strike to Andrew Fischer and a 15-yard score to Brate.
Stanton Jr. had 21 rushes for 113 yards.
Pruneau went 17-of-29 for 263 yards, with 103 of those going to Ricky Zorn.
Reed, who relieved Andrew Dzurik in the second half, was 17-for-22 with 235 yards and an interception for Lafayette.
Arizona State's talented defense has upper-echelon potential, especially along the line, but its high-risk style at times leaves it exposed.
Vanderbilt's bowl hopes likely require a fast start to the season, making the matchup against Georgia Tech cruical for Derek Mason's squad.
Penn State's James Franklin hopes that his offseason additions arrive with a more permanent feel for his staff and his program.
Fueled by the feel-good story of cancer survivor RB James Conner, the Panthers would love to pull off a feel-good win over in-state rival Penn State.
Wisconsin plans to use its speedy new weapon, four-star prospect A.J. Taylor, as a wide receiver when he arrives on campus this summer.
Travon McMillian will be a player Tennessee fans will want to keep an eye on when the Vols face Virginia Tech on Sept. 10.