Pruneau opened the scoring for the Crimson (5-0) with a 2-yard pass to Cameron Brate in the first quarter. Stanton Jr. ran for a 3-yard touchdown in both the second and third quarters.
Pruneau tossed two more touchdowns in the fourth quarter, a 50-yard strike to Andrew Fischer and a 15-yard score to Brate.
Stanton Jr. had 21 rushes for 113 yards.
Pruneau went 17-of-29 for 263 yards, with 103 of those going to Ricky Zorn.
Reed, who relieved Andrew Dzurik in the second half, was 17-for-22 with 235 yards and an interception for Lafayette.
Kevin Weidl and Marcus Spears look at the best fit, biggest surprise and best player left from the SEC after the first round of the 2016 NFL Draft.
Thirteen minutes before the draft, Laremy Tunsil's Twitter account was reportedly hacked, and a video of Tunsil smoking surfaced. The drama didn't end there, as the 13th pick dominated the headlines on draft night.
SEC Network checks into Mississippi State's spring football practice for a sneak peak at their offseason adjustments.
Kevin Weidl and Marcus Spears look at how former Ole Miss players Laquon Treadwell and Robert Nkemdiche will fit with the Vikings and Cardinals, respectively.
SEC Network's Peter Burns talks with Seattle Seahawks' 31st overall pick Germain Ifedi about the feeling of being drafted and his excitement for Seattle.
SEC Network's Peter Burns talks with Indianapolis Colts' 18th pick Ryan Kelly about his experience in the NFL draft and thoughts on playing in the NFL.