Pruneau opened the scoring for the Crimson (5-0) with a 2-yard pass to Cameron Brate in the first quarter. Stanton Jr. ran for a 3-yard touchdown in both the second and third quarters.
Pruneau tossed two more touchdowns in the fourth quarter, a 50-yard strike to Andrew Fischer and a 15-yard score to Brate.
Stanton Jr. had 21 rushes for 113 yards.
Pruneau went 17-of-29 for 263 yards, with 103 of those going to Ricky Zorn.
Reed, who relieved Andrew Dzurik in the second half, was 17-for-22 with 235 yards and an interception for Lafayette.
South Carolina has decided to give up Saturday's home game against No. 7 LSU because of devastating floods that have hit the state, moving the game to Baton Rouge.
Texas says longhorn steer mascot Bevo XIV has a "life-threatening condition" and won't travel to Dallas for the team's rivalry game Saturday against No. 10 Oklahoma at the Cotton Bowl.
West Virginia All-Big 12 safety Karl Joseph is out for the remainder of the season after injuring his knee during a non-contact drill in Tuesday's practice.
Rutgers has reinstated senior wide receiver Leonte Carroo a day after an assault charge against him was dropped.
Ole Miss cornerback Tee Shepard, who missed all of last season with a toe injury, has decided to give up football and focus on completing his college degree.
UCLA junior linebacker Myles Jack has withdrawn from school and will enter the NFL draft, making the decision just weeks after suffering a season-ending knee injury.