CSU (3-4, 1-1 Mountain West) ended a four-game losing streak to Wyoming (4-3, 2-1) and prevented the Cowboys from going 3-0 in conference play for the first time since 1998.
The Rams defense held the nation's No. 10 offense in totals yards per game average in check and forced three turnovers.
Bibbs, whose previous career-high in rushing yardage was 147, had TD runs of 7, 59 and 9 yards on 29 carries. He averaged 6.9 yards per rush.
Grayson completed 18 of 23 passes and had one interception. He was 15 of 18 in the first half when CSU gained a 24-7 lead. He completed TD passes of 24 yards to Kivon Cartwright, 22 yards to Austin Gray and 34 yards to Donnell Alexander.
Brett Smith led Wyoming, completing 21 of 36 passes for 246 yards and a touchdown.
Dominic Rufran caught seven of Smith's passes for 135 yards, including a 71-yard score.
CSU dominated the game from the outset, gaining a 21-0 lead as the Rams offense shredded the Cowboys defense for 289 total yards and averaged 6.4 yards per play in the first half.
By contrast, Wyoming's offense, which entered the game averaging 518.8 total yards a game, struggled. At one point early in the second quarter, CSU had outgained the Cowboys in total yardage 220-34.
Smith, who entered the game ranked third in the nation with an average of 379 total yards a contest, had just 78 passing and rushing yards in the half.
The Cowboys ended the game with 416 total yards.
CSU, which was averaging 403.3 yards a game, finished with 509.
A new study found that younger football players are more likely than those in high school and college to return less than a day after they suffer concussions.
Former Wildcat and current Green Bay Packer Randall Cobb becomes the first member of his immediate family to graduate from college.
SEC Network's Greg McElroy sits down with Tennessee quarterback Joshua Dobbs to relive some of his biggest moments from the season.
SEC Network's Spring Tour stops by Knoxville as head coach Butch Jones gets mic'd up at practice.
The Big 12's research shows that expanding the conference back to 12 teams will maximize its chances of making the College Football Playoff.
Now that the NFL draft is over, we take a look at possible replacements for the players selected from schools in the Pac-12 North.