Facing an early 3-0 deficit, the Cowboys (7-1, 3-0 Southland) scored touchdowns on three straight drives as Cody Stroud hit Diontae Spencer for a 5-yard score and Dylan Long had touchdown runs of 2 and 4.
Wiltz ran for touchdowns of 17 and 5 in the third quarter. Following a 4-yard score from Henderson to Buchanan, McNeese State's Khalil Thomas returned the ensuing kickoff 94 yards for a touchdown to fuel the rout.
Wiltz finished with 98 yards rushing on 14 carries. Kelvin Bennett ran for 169 yards on 13 attempts.
Ohio State quarterback Cardale Jones is "doing fine" after he was released from the hospital Wednesday night after being treated for symptoms related to a migraine headache.
Five Rutgers players were charged Thursday with crimes including assault and robbery, another jolt to a program whose coach is embroiled in an ongoing academics-related probe.
The Florida Gators will start Treon Harris at quarterback in Saturday's opener vs. New Mexico State over redshirt freshman Will Grier, coach Jim McElwain said Tuesday.
Baylor University has hired a Philadelphia law firm to independently investigate the university's handling of sexual assault complaints, including one against defensive end Sam Ukwuachu.
Oregon State and former coach Mike Riley face a federal Title IX lawsuit filed by a woman who said she was raped as a result of the coach's failure to correct a sexually violent culture.
James Madison players will wear decals on their helmets during Saturday's season-opening game in memory of the two journalists who were killed during a live television broadcast.