GLENDALE, Ariz. -- Kevin Kolb tried to downplay the significance of beating his former team, focusing more on the success of his current team.
In the huddle, the Cardinals quarterback couldn't hide his desire to knock off Philadelphia. He wanted this one bad.
Kolb orchestrated Arizona's offense to near perfection while building a big first-half lead and the defense hounded Michael Vick all day, sacking him five times to help the Cardinals run over the Eagles 27-6 on Sunday for their best start in 38 years.
"He was calling for guys to reach down and dig deep, that we really needed to make a play," Cardinals receiver Larry Fitzgerald said. "He really doesn't talk that much in the huddle, but today I could tell that he was extra motivated."
Kolb was sharp in his first start against his former team, throwing for 222 yards and a pair of touchdowns on 17-of-24 passing. He led the Cardinals to a 24-0 halftime lead, in part, by reconnecting with Larry Fitzgerald, who had one catch against New England last week.
The guest conductor for the Phoenix Symphony on Thursday, Fitzgerald kept the high notes going by catching nine passes for 114 yards and a touchdown while becoming the youngest player in NFL history to reach 700 receptions.
Adding to Kolb's satisfaction was the way Arizona's defense played against the man who pushed him out of Philly.
Harassing Vick from the opening snap, the Cardinals hit him hard and often, forcing him into two fumbles, including one that James Sanders returned 93 yards for a touchdown on the final play of the first half.
Backing up a big road win against the Patriots with a dominating victory over the Eagles, the Cardinals (3-0) are off to their best start since 1974, more than a dozen years before the team moved to the desert. They've also won seven straight home games, the second-longest streak in franchise history, and have won 10 of 12 dating to the end of last season.
"I'm going to enjoy it, don't get me wrong, but the biggest thing is being 3-0," Kolb said. "Being 3-0 with the teams that we've played and the fashion that we've won, it's been exciting."
The Eagles' season had been, too -- until they ran into Kolb and his Cardinals.
Philadelphia (2-1) became the first NFL team to open a season with two one-point wins. The Eagles didn't give themselves a chance to rally for another victory.
The NFL's best offense the first two games, the Eagles had three turnovers, running their season total to 12, and labored all day against the scrappy Cardinals, unable to keep them off Vick.
"They played better than we did, clearly better," Eagles coach Andy Reid said. "They coached better, they played better and that is my responsibility. I didn't have my football team ready to play and they did."
After three years of waiting behind Donovan McNabb, Kolb was pushed aside when Vick made his triumphant return to the NFL.
Even after being traded to Arizona and landing a huge contract extension, Kolb still had to fight for recognition.
He lost a tight preseason battle with Skelton, but came off the bench in the opener against Seattle when Skelton sprained his right ankle. Kolb took the Cardinals on the winning drive and was steady enough last week to lead them to one of their biggest road victories in recent years, 20-18 over the Patriots.
Skelton returned to practice late this week, but was limited and couldn't go Sunday.
Kolb made the most of his opportunity. He completed all three of his throws on Arizona's opening drive to set up Jay Feely's 16th straight field goal, from 47 yards.
After the Cardinals recovered a fumble by Eagles punt returner Damaris Johnson, Kolb threw an 8-yard TD pass to Michael Floyd, who made his first NFL catch a memorable one by juggling the ball through two Philadelphia defenders.
Kolb kept clicking in the second quarter, throwing a 37-yard touchdown pass to Fitzgerald that put the Cardinals up 17-0. He also helped Fitzgerald reach a big milestone in the quarter, hitting him on a 4-yard pass to reach 700 receptions in 29 years and 23 days and eclipse Dallas tight end Jason Witten, who became the youngest last week at 30 years and 133 days.
Arizona's offense bogged down in the second half -- 28 yards in the third quarter -- but ground the game away with a time-consuming, 13-play drive in the fourth quarter that resulted in a 27-yard field goal by Feely for a 27-6 lead.
Vick finished with 217 yards on 17-of-37 passing after entering the game second in the NFL with 688 yards.
"I wish I had all the answers right now," Vick said. "The only thing I can tell you is we didn't play our best, Nowhere near what we have potential to do."
Arizona has at least two sacks in nine straight games, the longest current streak in the NFL. ... Philadelphia played without receiver Jeremy Maclin (hip) and left tackle King Dunlap (hamstring). ... LaSean McCoy was Philadelphia's leading rusher with 70 yards on 13 carries. ... Arizona also won seven straight home games from 2007-08 and set the franchise record with nine straight in 1925.
Indianapolis Colts quarterback Andrew Luck will not play Sunday against the Jacksonville Jaguars because of a right shoulder injury.
Houston Texans running back Arian Foster is on the active roster and is expected to play against the Atlanta Falcons, marking his first game action since tearing his groin Aug. 3.
Jets receiver Eric Decker, who was listed as questionable with a knee injury, was active for Sunday's game against the Dolphins in London.
Bears quarterback Jay Cutler, who has been hampered by a hamstring injury, is active and will start Sunday's game against the Oakland Raiders.
Philadelphia Eagles running back DeMarco Murray, who has been hampered by a hamstring injury, is active and expected to play against the Washington Redskins on Sunday.
Tom Carpenter provides "live" reports and analysis on Week 4 inactives.