Brees threw for a season-high 371 yards and five touchdowns, carving up coach Bill Belichick's defense like few quarterbacks ever have in the Saints' 38-17 victory Monday night.
"It only counts for one win on the stat sheet, but emotionally, those types of wins can mean a little more," Brees said. "Anytime you can win, and win that way, it builds confidence for you."
By harassing Brady all game and routing one of the NFL's top powers, the Saints joined the Indianapolis Colts at 11-0 -- the first time two NFL teams have opened with that many consecutive wins in the same season.
The convincing victory left little doubt about New Orleans' credentials as the Saints try to match the Patriots' 16-0 regular-season mark in 2007. New England remains the only team to go undefeated in a 16-game regular season -- for now.
Brees threw touchdown passes to five different players: Pierre Thomas, Devery Henderson, Robert Meachem, Darnell Dinkins and Marques Colston. In doing so, the Pro Bowl quarterback kept New Orleans on pace to narrowly eclipse New England's single-season scoring record of 589 points set in 2007.
"He was special," Saints coach Sean Payton said. "Let's just say he's playing really well."
The Saints averaged 9.6 yards per play, a club record that Brees called "ridiculous."
Brees went 18 of 23 and finished with a perfect passer rating of 158.3. His average of 16.1 yards per passing attempt also was a team record.
"We were able to accomplish something offensively tonight that was pretty special," Brees said.
It was the second time the Patriots (7-4) lost to an unbeaten team on the road in three weeks. Unlike in Indianapolis, there was no drama at the end this time, only thunderous chants of, "Who dat say they gonna beat them Saints?"
"There's obviously a big gap between us," Brady said. "It wasn't nearly as competitive as we all were expecting."
Brady, returning to the Louisiana Superdome for the first time since leading the Patriots to their first Super Bowl title in 2002, won't have many fond memories of this game. He was intercepted twice, sacked once, hit as he threw several times and pulled from the game in the fourth quarter with New Orleans leading by three TDs.
"There's a reason why they are 11-0," Brady said. "They played really well and we didn't play up to their level."
Brady finished 21 of 36 for 237 yards and did not throw a TD pass. He did, however, become New England's career passing leader, eclipsing Drew Bledsoe's mark of 29,657 yards.
New Orleans needed only three plays to get it back, though. Brees hit Colston along the right sideline and the receiver turned it into a 68-yard gain by eluding Jonathan Wilhite's tackle. That set up tight end Dinkins' first TD of the season on a 2-yard pass to make it 31-17.
Belichick called his defense "really bad."
"We had several blown coverages and they took advantage," he said. "There were enormous mistakes on our part. You can't make those mistakes against a good team."
Clearly worried about his club's ability to stop Brees, Belichick made his latest unconventional fourth-down call.
Unlike in Indianapolis, where the Patriots tried to put the game away by going for it in their own territory late in the fourth quarter, New England this time went for it on fourth-and-4 from the New Orleans 10 in the third quarter.
Brady's pass for Moss along the left sideline was broken up by Mike McKenzie, who was playing for the first time since fracturing his right kneecap a year ago. The play preserved New Orleans' two-touchdown lead.
McKenzie apparently had little trouble learning the system of new Saints defensive coordinator Gregg Williams. McKenzie also had an interception in the first half that stalled a promising Patriots drive and led to a Saints score. Darren Sharper intercepted Brady in the fourth quarter, ending the quarterback's night.
Brees' scoring passes of 18 yards to Thomas, 75 yards to Henderson and 38 yards to Meachem gave New Orleans a 24-10 lead at halftime.
Brees -- who threw six TDs in Week 1 against Detroit -- made the long TD to Henderson look easy, recognizing that Wilhite's blitz had left the receiver wide open. Brees' 20-yard TD pass to Colston with 7:49 to go left little doubt about the outcome.
The Saints have 22 interceptions this season, which leads the NFL. Sharper has eight. ... Saints CB Chris McAlister, signed two weeks ago, played for the first time since having surgery on his right knee a year ago. ... The Saints said cornerback Randall Gay had a leg injury but were not more specific. ... New England lost a regular-season game in New Orleans for the first time after winning its previous four.
For the second time this season, Texans coach Bill O'Brien is considering an in-season quarterback change.
Receiver Andre Johnson picked the perfect time to catch his first touchdown as a member of the Indianapolis Colts.
Texans running back Arian Foster was taken to the locker room in the second quarter of Thursday night's 27-20 loss to the Colts with an unspecified injury.
The Miami Dolphins fired defensive coordinator Kevin Coyle on Thursday after four seasons with the team and promoted defensive backs coach Lou Anarumo to take his place.
Jay Cutler said on Thursday he's not 100 percent but is pushing through his hamstring discomfort in light of all the injuries the Bears have suffered this year.
Dallas Cowboys coach Jason Garrett spoke with defensive end Greg Hardy regarding his comments about returning "guns blazing," and about the wife of New England Patriots quarterback Tom Brady.