DETROIT -- The Detroit Lions moved a step closer toward putting their miserable past behind them, winning for the first time this season and by their largest margin in 15 years.
"It feels good to get this one so we can move on," center Dominic Raiola said.
Detroit (1-4) hadn't won since Nov. 22, 2009, when Matthew Stafford threw five touchdown passes against Cleveland after getting briefly knocked out of the game.
The Lions, who had the NFL's first 0-16 season two years ago, had won just three of their previous 44 games. They had a shot to win three of their first four games -- losing by five, three and two points -- after their 14 losses last season were by at least a TD and several were very lopsided.
"Our players understood how close we were," second-year coach Jim Schwartz said. "But you need validation."
The Lions won by more than a touchdown for the first time since Nov. 4, 2007, when they beat Denver 44-7.
Clayton, whose injury appears serious, fell to the ground while running a pattern and stayed down until he was carted off the field.
"It doesn't look good," St. Louis coach Steve Spagnuolo said.
Bradford, coming off his best game, had one of his worst. He was 23 of 45 for 215 yards with two interceptions, one that was batted into the air and caught by Ndamukong Suh and one directly to Alphonso Smith, who returned it for the final score.
"There are going to be a lot of things that we have to find on the film and fix because we have to make sure this never happens again," said Bradford, who was drafted this year No. 1 overall just ahead of Suh. "I don't think I've ever been part of a loss like this."
Playing again in place of last year's No. 1 pick Stafford, Shaun Hill threw for 227 yards and connected with Calvin Johnson, Brandon Pettigrew and Nate Burleson for touchdowns. Hill has started since Stafford separated his right shoulder in Week 1.
"Even though we don't have Matt, we have somebody who can hold down the fort," said Burleson, who was flagged for punting the football into the stands after his TD.
The Lions got off to a good start because a risky move backfired for St. Louis, which started game with a failed onside kick.
"Maybe the biggest play that gets overlooked was the opening kickoff," Schwartz said.
Logan's return was easy to notice.
He went from the middle of his end zone and raced to the other -- breaking one tackle along the way -- for a 10-3 lead to make his mom and dad, who has kidney failure, two of the happiest people at Ford Field.
"I wanted to do it so bad because my parents were out here and I wanted to show off for my parents," Logan said. "My dad, he's sick so he can't just come up to a game every other week."
At least one kickoff has been returned for a score in the first five weeks of a season for the first time since at least 1950, including AFL games before the 1970 merger, according to STATS.
Logan's TD tied the longest in franchise history and helped the Lions outscore St. Louis 21-3 in the second quarter.
Steven Jackson did his part for the Rams, running for 114 yards on 25 carries, but he didn't have much help without Clayton on the field. Clayton started the game among NFC leaders in receptions and yards receiving.
"Everyone has seen what he's done for this offense in the first four games, and it is going to be tough to replace him," Bradford said. "We just need someone to step up."
The Lions beat the expansion Jacksonville Jaguars 44-0 in 1995. ... Rams G Jacob Bell and TE Darcy Johnson had concussions. ... Lions DE Cliff Avril left the game with cramps. ... Steelers defensive coordinator Dick LeBeau, whose team had a bye, was presented with his Pro Football Hall of Fame ring during a halftime ceremony. ... Lions DE Kyle Vanden Bosch confirmed the team voted Thursday to give the NFL Players Association its backing to decertify the union if there is a labor lockout next year. By disbanding their union, the layers could sue the NFL under antitrust laws if there is a work stoppage. A similar move following a 1987 labor impasse led to the 1993 agreement that created free agency.
Brian Hoyer is the Houston Texans' starting quarterback for the team's Week 6 game against the Jaguars. For how long he remains beyond that game is uncertain.
The Seattle Seahawks have ruled running back Marshawn Lynch out for Sunday's game against the Cincinnati Bengals due to a hamstring injury.
San Francisco 49ers tight end Vernon Davis, despite practicing in a limited fashion all week with a knee injury, has been ruled out for Sunday night's game at the New York Giants.
New Orleans Saints first-round draft pick Andrus Peat will make his starting debut at left tackle against the Eagles in place of injured Terron Armstead.
Stephen Gostkowski of the New England Patriots is the best kicker in the NFL, according to an NFL Nation survey of his peers.
Detroit Lions vice chairman Bill Ford Jr. said Friday on WJR Radio that his mother, owner Martha Ford, is in full control of the franchise.