His mistake helped put the Carolina Panthers in a deep hole Sunday, but Newton knew how to get out.
He led a late comeback for the second time in a week, converting a fourth-and-10 situation at his 20 with a completion to keep alive the Panthers' final possession, and their touchdown with 43 seconds left beat Miami 20-16.
The Panthers (8-3) overcame a 16-3 first-half deficit for their seventh win in a row, their longest streak since 2003.
"It may not be pretty," Newton said, "but at the end of the game we get that three-letter word, and that's gorgeous."
The Dolphins (5-6) fell to 2-2 since tackle Jonathan Martin left the team and the team's bullying scandal began to mushroom.
"We've got to make plays at the end when it counts," receiver Mike Wallace said. "We've got to have a killer instinct. I don't think we have it that well right now. We've got to do a better job of putting teams away."
The Panthers trailed 16-13 when their winning drive began at their own 20 with 4:13 left. With only one timeout remaining, they went for it on fourth down, and Newton threaded a pass between two defenders to Steve Smith for a 19-yard gain.
A backbreaker for Miami?
"I'm not sure there's any other word to describe that," defensive lineman Jared Odrick said.
"That's when the tide shifted in our favor," Newton said.
Carolina then converted two third downs before Newton hit Olsen for the winning score.
Ryan Tannehill nearly connected with Wallace for a 60-yard score in the final seconds, but the pass fell incomplete at the goal line.
"That's a tough play," Tannehill said. "You're basically a hope and a prayer and get it out there."
"A little scary," Carolina coach Ron Rivera said.
Tannehill and Wallace earlier teamed up for a 53-yard touchdown and a 57-yard completion to set up a field goal.
Newton's interception led to another field goal by Miami. He was erratic at the outset, perhaps partly because he bit his tongue when hit on the first series, and he finished with a quarterback rating of only 60.6.
But Newton was at his best with time running out. Following the Panthers' uncharacteristically slow start, he led them 52 yards for a field goal in the final 61 seconds of the first half with no timeouts left, taking advantage of Miami's soft coverage to cut the deficit to 16-6.
Rivera's willingness to take chances paid off in the third quarter. From the Panthers 41, Newton ran for 8 yards to convert a fourth-and-1, and they went on to complete an 83-yard touchdown drive to make the score 16-13.
"They have been calling our coach Riverboat Ron because he likes to gamble," Newton said.
Newton scored on a 5-yard keeper in the third quarter and celebrated with a dance tribute to LeBron James, mindful he was in the Miami Heat star's area code.
"Three-oh-five is where he reigns supreme with Dwyane Wade and Chris Bosh," Newton said. "I'm big fans of those guys."
For the second game in a row, the Panthers' Luke Kuechly made a big play in the end zone that was disputed. He appeared to make helmet-to-helmet contact when he broke up a potential touchdown catch by Rishard Matthews, and an official threw a flag, but the referee determined there was no penalty and Miami settled for a field goal and a 16-3 lead.
Kuechly bear-hugged the Patriots' Rob Gronkowski on the final play of the Panthers' victory at New England last Monday.
While Tannehill threw for 280 yards, he was also sacked three times to increase his season total to 44, a franchise record. Carolina held Miami's running backs to 16 yards in 13 carries and shut out the Dolphins over the final 31 minutes.
"We were lazy in the first half," Carolina's Smith said. "We underestimated that team."
The Dolphins fell to 4-4 in games decided by four points or less.
"We were a couple of plays away from winning," Tannehill said. "We've got to be able to make those plays. It's tough to win three-point games every week. When the defense is playing well like that, we've got to be able to score more points."
Miami RB Daniel Thomas left the game in the third quarter with a left ankle injury. ... The Panthers had been 0-4 previously against Miami. ... Ted Ginn Jr. dropped a potential 50-yard catch playing in Miami for the first time since he left the Dolphins as a first-round bust following the 2009 season. ... The Dolphins announced their annual cycling event has raised $3.1 million for the University of Miami Sylvester Comprehensive Cancer Center.