| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Josh McCown |
1. Josh McCown, QB | ARI | L 24-20 vs. CAR | 29 | 46 | 398 | 2 | 3 | 1 | 0 | 78.0 |
| 2. Tom Brady, QB | NE | W 31-28 at ATL | 22 | 27 | 350 | 3 | 1 | 1 | 0 | 140.4 | |
| 3. Marc Bulger, QB | STL | L 37-31 vs. SEA | 26 | 40 | 336 | 2 | 1 | 4 | 0 | 97.5 | |
| 4. Mark Brunell, QB | WSH | L 21-19 at DEN | 30 | 53 | 322 | 2 | 0 | 0 | 1 | 87.1 | |
| 5. Matt Hasselbeck, QB | SEA | W 37-31 at STL | 27 | 38 | 316 | 2 | 0 | 4 | 0 | 113.5 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Thomas Jones |
1. Thomas Jones, RB | CHI | L 20-10 at CLE | 24 | 137 | 5.7 | 0 | 25 | 0 | |
| 2. Fred Taylor, RB | JAC | W 23-20 vs. CIN | 24 | 132 | 5.5 | 0 | 17 | 0 | ||
| 3. Domanick Williams, RB | HOU | L 34-20 vs. TEN | 19 | 130 | 6.8 | 0 | 44 | 0 | ||
| 4. Tatum Bell, RB | DEN | W 21-19 vs. WSH | 12 | 127 | 10.6 | 2 | 55 | 0 | ||
| 5. Shaun Alexander, RB | SEA | W 37-31 at STL | 25 | 119 | 4.8 | 2 | 18 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Anquan Boldin |
1. Anquan Boldin, WR | ARI | L 24-20 vs. CAR | 10 | 162 | 16.2 | 1 | 46 | 1 | |
| 2. Joe Jurevicius, WR | SEA | W 37-31 at STL | 9 | 137 | 15.2 | 1 | 52 | 0 | ||
| 3. Larry Fitzgerald, WR | ARI | L 24-20 vs. CAR | 9 | 136 | 15.1 | 1 | 47 | 0 | ||
| 4. Torry Holt, WR | STL | L 37-31 vs. SEA | 8 | 126 | 15.8 | 1 | 26 | 0 | ||
| 5. Steve Smith, WR | CAR | W 24-20 at ARI | 8 | 119 | 14.9 | 2 | 65 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Donnie Edwards |
1. Donnie Edwards, LB | SD | L 24-22 vs. PIT | 13 | 2 | 15 | 0.0 | 0 | 0 | 0 |
| 2. Keith Bulluck, LB | TEN | W 34-20 at HOU | 12 | 3 | 15 | 1.0 | 0 | 0 | 0 | |
| 3. Zach Thomas, LB | MIA | L 20-14 at BUF | 11 | 4 | 15 | 0.0 | 0 | 0 | 0 | |
| 4. Jonathan Vilma, LB | NYJ | W 14-12 vs. TB | 11 | 3 | 14 | 0.0 | 1 | 0 | 0 | |
| 5. Victor Hobson, LB | NYJ | W 14-12 vs. TB | 9 | 4 | 13 | 0.0 | 0 | 0 | 0 | |
