Regehr, Stafford and Kaleta practiced Monday and hope to be ready for Tuesday's contest.
"It's the longest (injury) list I've seen since I've been here," said coach Lindy Ruff, who has been with the team since 1997.
Luke Adam made up for the missing production, scoring twice.
"You have to play hard every night regardless if you have your full lineup or not," Adam said. "You can't afford to make mistakes, and you need everyone going every night."
Though New York has struggled to score this season, that hasn't been the case in recent games against Buffalo. The Islanders have registered at least five goals in three of the last five matchups, including a 7-6 overtime victory Feb. 13 in the most recent meeting.
Grabner, who scored the game-winner, and Stafford each had a hat trick in that contest. Grabner has six goals and an assist in four career games versus the Sabres, while Stafford has six goals and five assists in 13 against the Islanders.
John Tavares has notched a point in seven of his eight career contests against Buffalo, totaling six goals and five assists.
New York has won two straight road games against Buffalo, which ended a three-game home losing streak Saturday.
AccuScore has powered more than 10,000 simulations for every NHL game on ESPN.com, calculating how each team's performance changes in response to game conditions and opponent's abilities. Each game is simulated and the game is replayed a minimum of 10,000 times to generate forecasted winning percentages.